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The basis for the enhanced toxicity is that chronic ethanol exposure can induce Cyp2E1 enzyme activities and thus enhance NAPQI formation [175]

Insulin enhances glucose uptake into hepatocytes, activates glycogen and FFA synthesis (in adipocytes), and accelerates cellular glucose metabolism, whereas THs increase hepatic glucose output, increase GLUT2 expression in hepatocyte membranes, inhibit glycogenesis, and activate gluconeogenesis [25]

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The peptide as well as its Cu (II) chelate have anti-inflammatory and tissue remodeling properties

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