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ZD: Investigation, Writingoriginal draft

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Introduction Im from Charlottesville, Virginia

Despite the potential of TNF- ablation therapies, caution is required in their application because TNF- is critical for the anti-tumor activity of cytotoxic NK and T cells, and its complete neutralization may inadvertently impair these immune cells functions

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In a study conducted by Labib et al., four innovative series of tetrazole analogs were developed by bioisosteric substitution of the sulfonamide moiety in celecoxib (Figure 5) with tetrazole, incorporating various core structures such as chalcone, isoxazole, and pyrazole (96)