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doi: 10.1016/j.nbd.2020.104784 396 WormserG

Recombinant lentiviruses were produced by transfecting HEK293T cells with pCMV-VSV-G (VSV-G protein), pCMV-dR8.2 (lentivirus packaging vector) and shRNA-expressing constructs using Lipofectamine 2000 transfection reagent as previously described

AOD-9604 is generally well-tolerated with a favorable safety profile based on clinical research involving approximately 900 participants across six studies

12 units

The peptide accelerates repair across a range of injury types (muscle tears, fractures, tendon ruptures, and surgical wounds) by simultaneously targeting inflammation, vascularization, and cellular regeneration

The tendon tissue is damaged but not completely severed