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The skin substitutes exposed to both cigarette smoke and solar rays presented an aged profile with a decreased protein expression of collagens, induced by the inhibition of Smad2 phosphorylation leading notably to a decrease in procollagen synthesis, and the activation of MMP activity

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The BFI London Film Festival (4 to 15 October 2023) presents a selection of the best in world cinema, showing audiences a wide array of films, representing a variety of languages, genres and filmmaking styles