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When peroxisomal catalase activity is compromised, excess HO diffuses into mitochondria, disrupting their dynamics and exacerbating oxidative stress

We are awaiting publication.) As for a drug that might be more effective at reducing lactate, we did conduct a clinical trial of precisely such a drug dichloroacetate or DCA in patients with the syndrome of Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes (MELAS), a primary mitochondrial disorder with gallons of ventricular lactate