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Effects of brain-penetrating ACE inhibitors on Alzheimer disease progression

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Nrf2 attenuates ferroptosis-mediated IIR-ALI by modulating TERT and SLC7A11

This stabilizes the IREB2 protein and subsequently activates the downstream TFRC expression

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The GSH-mediated decrease in oxidative stress is via its antioxidant effect in the direct or indirect ROS scavenging systems, thus decreasing MDA production, restricting As uptake, or altering the antioxidant scavenging system involved in decreasing ROS levels