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The combined activation of all three pathways is hypothesised to produce more pronounced and sustained weight reduction, though the long-term clinical implications of each receptor's contribution remain to be fully established

LCZ696 protects against doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via AKT/SIRT3/SOD2 signaling pathway activation

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Distinct pathophysiological processes contribute to the rewiring of specific metabolic pathways and the development of vulnerabilities