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Several studies (Table 3) have shown that LA significantly reduces body fat mass, hepatic clearance of TG-rich lipoproteins, and lipid droplets through upregulating the expression levels of hepatic lipolytic enzymes (ATGL, acyl-CoA thioesterase [Acot1], Acot2, Acsf2, and Crat) and downregulating the expression levels of liver lipogenic enzymes (patatin-like phospholipase domain protein [Pnpla3], Pnpla5, Elovl6, Acly, sn-glycerol-3-phosphate acyltransferase 1 [Gpat], Aacs, FASN, ACC, and SCD-1)

Gao et al., 2024)

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Increased inflammatory cells, especially in the portal space connective tissues, were reported in the rats that were fed with a high Met diet (34)

10.3390/ijms21010265 81 NagyL

Boosts liver function Fatty liver disease, or steatosis, is a condition characterized by fat accumulation in the liver