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It is used to treat fluid retention (edema) in people with congestive heart failure, liver disease, or a kidney disorder such as nephritic syndrome

Amylin (also called islet amyloid polypeptide, or IAPP) is a 37-amino acid peptide hormone co-secreted by the beta cells of the pancreas alongside insulin, typically in response to meals

A potential underlying mechanism involves attenuated phosphorylation of p53 at Ser46, which inhibits p53-mediated apoptosis and ferroptosis (Zhang et al., 2022)