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At the respective analysis point, the medium was removed, washed with 200 l PBS and replenished with 200 l fresh medium per well

This metabolic perturbation further indicated that elevated ROS levels upon GGCT suppression contribute to TCA cycle dysfunction

In del[13q]CLL cells, the microRNA (miR) cluster miR-15a/miR-16-1 is deleted, leading to the loss of its tumor suppression function and overexpression of the antiapoptotic proteins B-cell lymphoma-2 (BCL-2) and myeloid cell leukemia-1 (MCL-1)

Total oxygen consumption capacity (TOCC) The results for TOCC are shown in Fig

DMF mediates NRF2-dependent and independent mechanisms on TSS pathway CBS activation DMF activates NRF2, the master regulator for the antioxidative stress response, to regulate the expression of proteins involved in iron hemostasis, and GSH synthesis such as HMOX1, NQO1, FTH, FTL, SLC40A1 in a variety of cellular systems 37