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These modifications have been hypothesized to play a crucial role in the diffusion of DNA damage response/senescence-associated secretory phenotype (DDR/SAPS) signaling to non-damaged surrounding cells during aging, suggesting that DDR/SASP signaling components may contribute to the development of novel therapeutic interventions against age-related diseases (Olivieri et al., 2015)

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A nucleophilic center is then formed at the carbon next to the carboxyl group as a result of electronic rearrangement

Women typically carry a higher percentage of body fat with preferential storage in gluteofemoral regions (hips, thighs, buttocks), while men tend to accumulate visceral and abdominal subcutaneous fat