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Running 8-week cycles with 4-week breaks means approximately 8 months of active use per year rather than 12

Efficacy and safety of triple combination therapy with artesunate-amodiaquine-methylene blue for falciparum malaria in children: a randomized controlled trial in Burkina Faso

Disadvantages: Biocompatibility: Potential for activation of complement pathways, leading to infusion-related reactions if not properly optimized

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