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Additionally, tirzepatide administration over an extended period raised BAT levels of several amino acids that have been demonstrated to be elevated in response to cold exposure

[DOI] [PMC free article] [PubMed] [Google Scholar] 142.Macci A, Madeddu C

However, better characterization of IL-22 effects in MASH, as well as determination of the disease stage at which Th22 responses are most significant, may help clarify whether enhancing the activity of this subset is a viable therapeutic strategy

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This reduction is significant because this virus has been shown to exacerbate A neurotoxicity and oxidative stress in patients with AD [194]