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doi: 10.1097/YCO.0000000000000379 8 ShenXMiaoSZhangYGuoXLiWMaoXet al

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Clinical interventional with placebo supplementation for three months did not produce any changes in these cytokines levels

L-carnitine supplementation did not significantly affect the serum d-ROM levels after 1 month

Moreover, aged mice have been shown to be more susceptible to the release of proinflammatory cytokines and DNA oxidation from the same CS exposure than young mice with proper robust adaptive responses [16]

At certain concentrations and time points, overstimulation may suppress rather than enhance melatonin output, highlighting the importance of dose, timing, and context when considering clinical protocols [1]