Deletion of A
This finding agrees with the literature whereby the role of quinone redox metabolism is an ambiguous source of toxicity, with evidence suggesting that redox cycling requires supra-pharmacological concentrations of doxorubicin to generate substantial ROS in tissues and cells 10
[DOI] [PMC free article] [PubMed] [Google Scholar] 193.Kaur C., Tripathi A.K., Nutan K.K., Sharma S., Ghosh A., Tripathi J.K., Pareek A., Singla-Pareek S.L., Sopory S.K
Intensiv Care Med 37(7):11201127 Mahmoodpoor A, Hamishehkar H, Sanaie S, Behruzizad N, Iranpour A, Koleini E, Nader ND (2018) Antioxidant reserve of the lungs and ventilator-associated pneumonia: a clinical trial of high dose selenium in critically ill patients
Int Care Med
Alpha and Mu classes of GST2 superfamily enzymes, able to protect the cell from toxic endogenous or xenobiotic compounds, are abundantly expressed in rat liver, where they represent 43% and 56%, respectively, of the entire pool of cytosolic GSTs [54]