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2 Discovery of sulforaphane and the NRF2-ARE pathway Sulforaphane is an isothiocyanate, derived from the precursor glucoraphanin (Fahey et al., 1997

& Filfilan, W

Allen and Mieyal, 2012

Third, long-term safety data are scarce

43 In addition, hormonal levels have been implicated in the pathology of RA, 44,45 but the association with ACPA has not been firmly established

Its also worth noting that Novo Nordisk isnt the only company interested in amylin-based approachesRoche and Zealand Pharma are developing a separate amylin analog called petrelintide, underscoring the broader industry interest in this pathway