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Some studies have proposed that inhibition of autophagy can affect the progression of OA by causing chondrocyte apoptosis through mitochondrial dysfunction, so the knockdown of the mTOR signaling pathway can improve the balance between synthesis and degradation of chondrocyte extracellular matrix in osseous joints (128)

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The rats were obtained from Shahid Beheshti Medical University, weighed between 220 20 g, and were 8 weeks old

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