The critical role of p53 in IBD-associated ferroptosis has been confirmed in colonic tissues from CD patients and in a colitis model using HT29 cells
Polyphenols, found in blueberries and green tea , have demonstrated protection against oxidative damage in red blood cells (Youdim 2000)
Clinical trials in centenarians demonstrate that L-Carnitine treatment (2 g/day for 6 months) significantly reduces severity of physical and mental fatigue, improves muscle mass while reducing total fat mass, and enhances walking capacity and cognitive functions
Pharmacological IDO1 inhibitors (e.g., INCB023843 and RY103) lower MDSC burden and restore CD8 + T-cell infiltration in preclinical settings (52, 53)
Everything is made following Good Manufacturing Practices, just like it should be
Green, 10 February 2025, Annals of Neurology