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The peptide is small enough (three amino acids plus a copper ion) to penetrate the stratum corneum, particularly when formulated with phospholipid-based delivery systems that enhance dermal absorption
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The review concluded that NNMT plays important roles in obesity and type 2 diabetes and validated 5-Amino-1MQ as a potent small-molecule NNMT inhibitor that reverses diet-induced metabolic changes, establishing it as a primary research tool for the NNMT pathway
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