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Electrostatic interactions between the AgNP@CMC (coreshell nanostructure) and DOX were used to create a colloidal nanostructure

Introduction Multiple sclerosis (MS) was identified as a clinical entity almost two centuries ago and to this day remains somewhat of an enigma in terms of its fundamental cause (Clanet, 2008

Accumulating evidence shows that activation of Nrf2 upregulates key genes involved in redox homeostasis, including SLC7A11, glutathione synthetase, and glucose-6-phosphate dehydrogenase, thereby increasing the production of reduced cofactors such as NADPH, GSH, and CoQ10, which collectively enhance cellular antioxidant capacity and counteract disease-associated oxidative stress (277)

In most cases, weight loss resumes after the plateau, either spontaneously or with a dose adjustment

Repletion of iron stores (ferritin levels over 40, optimally between 50-75) either by oral supplementation, or injectable when warranted, can help replete both mitochondrial and hematologic iron stores