Melatonin , a hormone regulating sleepwake cycles, was also found to reduce cataract progress by increasing glutathione levels, and inhibiting polyol pathway enzymes, suggesting its potential as an endogenous antioxidant [49, 50]
The metabolites cyclic 3-hydroxy melatonin, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), and N1-acetyl-5-methoxykynuramine (AMK), which can reduce free radicals, are formed when MLT reacts directly with free radicals, including hydroxyl (OH ), superoxide (O 2 ), and reactive nitrogen species, such as nitric oxide (NO ) The hypothesis that MLT has a multifunctional role as a mitochondrial antioxidant is supported by numerous investigations [116,117,118]
It supplies bioactive forms of four essential B vitamins along with betaine (trimethylglycine or TMG)
(2003) Delta sleep-inducing peptide: effect on oxidative stress in brain during different models
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Inflammation was assessed using the Evans blue plasma extravasation technique and histology
