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B12 deficiency develops when the body does not have an adequate amount of B12 vitamins, which are an important nutrient and serve for general well-being

Relevant in vivo and in vitro experiments have confirmed that IGFBP-L1 methylation exerts a pro-oncogenic effect by promoting PI3K/AKT phosphorylation and IGFBP-L1 methylation has become a potential marker for the early detection of esophageal cancer, as well as a predictive marker for PI3K-targeted therapy in esophageal cancer (85)

However, the mechanism through which AZT inhibits complex I or succinate-linked respiration is still not clear