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4.3.2 SIRT1/Nfr2/HO-1/GPX4 The activity of Nrf2 signaling is enhanced by SIRT1 via increasing its expression, decreasing the expression of Keap1, and promoting its binding ability to antioxidant response element (ARE) (the promoter region of downstream antioxidant enzymes) (Patel et al., 2022)

Methylxanthines like caffeine and theobromine stimulate the central nervous system (CNS) and heart to promote wakefulness and motivation

Lastly, it's important to have realistic expectations

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Its crucial to discuss this risk with your surgeon during your consultation

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