This NO-dependent impact of rosuvastatin may have a significant effect on the microcirculation and can offer new potential for statin therapy application in the clinic [104]
Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells
The molecular basis of lutealization and progesterone synthesis is the presence of core steroidogenic genes (STAR, CYP11A1, LHCGR, and PGR) and transcriptional regulators (SF-1, FOXO1 and LRH-1), whereas endocrine signaling (MAPK/ERK, PI3K/AKT, and WNT/-catenin) fine-tune luteal cell survival, angiogenesis, In addition to classical hormonal regulation, new evidence also indicates that metabolic-epigenetic integration is central in the process of defining luteal fate, where AMPK can serve as an important sensor of energy, PPAR can be a context-specific transcriptional regulator of lipid metabolism and cell fate choices, and H3K27me3, which is mediated by EZH2, is a stable manner in which steroidogenic genes are repressed in luteal regression
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These two pathways are additive
doi:10.1016/j.biopha.2021.111468 Wei W, Zhao H, Wang A, et al
