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When cells are exposed to ferroptosis inducers, the SQSTM1/p62Keap1Nrf2AKR1C (metal-binding protein MT-1G) pathway is activated, and then activating transcription of quinone oxidoreductase-1, HO-1, and ferritin heavy chain-1, reducing the sensitivity of ferroptosis in the end (Sun et al., 2016b)

2016 May 10;6:e807. PMID: 27163208

It is thought to do this by stimulating human growth receptors in injured tissue

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Feng X, Li X, Liu N, Hou N, Sun X, Liu Y

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