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doi: 10.1038/s41598-024-68599-x 118 LardelliM.BaerL.HinN.AllenA.PedersonS

When IGF1 LR3 binds to the alpha subunits on the extracellular surface, it induces a conformational change that brings the intracellular beta subunits into proximity, triggering their autophosphorylation on specific tyrosine residues

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The initial value for the CYP enzyme (C) is normalized to 1 and the initial value of NAPQI (N) and damaged hepatocyte (Z) are set at 0, healthy hepatocyte (H) set to maximum, Glutathione (G) set to steady state value