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Even just one cigarette or smoking occasionally can harm your health

I saw smoking as more illicit than most drugs

Nicotine and chemicals in e-cigarettes can harm the inner lining of blood vessels and reduce nitric oxide levels, leading to poorer blood flow

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Despite the obvious biologic plausibility, the lack of consistent epidemiological evidence might be due to methodological issues including lack of cohort follow-up time into older adulthood (when lung cancer usually becomes clinically manifest), small sample sizes, selection and recall biases, and lack of adjustment for tobacco use in the statistical modeling