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Primary Research Areas NNMT enzymology and pharmacology the lead first-in-class selective small-molecule NNMT inhibitor used to validate the entire target class [1,2]

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Two compounds frequently discussed in this context are NAD (nicotinamide adenine dinucleotide) and Glutathione

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However, Besnier et al (104) reported that hypertonic sodium lactate solutions protected against cardiac dysfunction, microcirculatory impairment and vascular leakage in septic animals, while simultaneously attenuating inflammation and promoting ketogenesis