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10.3389/fnut.2023.1214420 23 BedardK.KrauseK
The most common issue is that someone with high serum B12 may actually be deficient in intracellular B12, but they dont receive treatment for the deficiency
However, a direct comparison of these results was not possible due to a lack of congruence between the (a) age groups investigated, namely, clear-cut young and old groups (MRS (Emir et al., 2011, Hupfeld et al., 2021)) versus young + middle-aged and old groups (biochemical assay (Tong et al., 2016)), and/or (b) specific ROIs used: medial frontal (Hupfeld et al., 2021) versus prefrontal dorsolateral cortex (Tong et al., 2016), and occipital cortex (Emir et al., 2011) versus primary visual cortex (Tong et al., 2016)
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