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Guidelines under the international tobacco treaty, the World Health Organization (WHO) Framework Convention on Tobacco Control (WHO FCTC), recommend that countries consider implementing plain packaging on cigarette packages

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TLR3, TLR7, melanoma differentiation-associated protein (MDA5), or retinoic acid-inducible gene RIG-I, could elevate baseline interferon signaling, particularly type III interferon responses at epithelial barriers, maintaining partial activation of interferon-stimulated genes without overt inflammation

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