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Beyond this classic signaling pathway that is widely implicated in tumorigenesis, GGCT could also regulate the Notch-Akt axis to facilitate the uncontrolled proliferation and aggressive growth of glioma cells [14]

Balakrishnan, M

Toxicol In Vitro

Moreover, some studies have shown that the ChaC1 protein is significantly upregulated in various adverse conditions, such as diabetes, viral infection and atherosclerosis, providing cells with the amino acid nutrients they need under stressful situations but reducing GSH levels

2.2 Patient samples Peripheral blood was obtained from 30 treatment-nave patients with CLL who provided written informed consent as part of a protocol approved by the Institutional Review Board of MD Anderson Cancer Center and in accordance with the Declaration of Helsinki

This is an extreme scenario that proper dosing and monitoring makes virtually impossible