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Moreover, SSR504734, another potent GlyT1 inhibitor, demonstrated positive results in MEST models across various dose levels (3.030 mg/kg, p.o.) with positive effects observed in rats and mice (Kalinichev et al

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The inflammatory markers include C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) (Victor et al., 2015) and animal models (Rabah et al., 2023)