Additional Recommendations for B12 Deficiency Management Adherence to Treatment Plan: Strictly follow your healthcare providers prescribed treatment plan, avoiding any skipped doses of medication or supplements
A 2021 systematic review of 16 randomized controlled trials and 6,276 participants (Markun and colleagues, Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue, Nutrients, 2021) found that B12 supplementation does not reliably reduce fatigue in people who are not deficient
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