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We hypothesize that SAC inhibits the E3 ubiquitin ligase activity of KEAP1 through interaction, thereby blocking the ubiquitination-mediated degradation of NRF2, stabilizing the NRF2 protein, and activating the transcription of various protective genes, including antioxidant enzymes

Red cell-bound antibodies and transfusion requirements in hospitalized patients with COVID-19

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van de Meeberg et al

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Ferraz CR, Carvalho TT, Manchope MF, Artero NA, Rasquel-Oliveira FS, Fattori V, Verri WA Jr (2020) Therapeutic potential of flavonoids in pain and inflammation: mechanisms of action, pre-clinical and clinical data, and pharmaceutical development