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This fact known as the gateway effect of e-cigarettes for nicotine dependence and cigarette smoking is of particular importance, as the extensive body of literature provides unequivocal evidence that tobacco use in the form of cigarette smoking is the leading preventable cause of premature death and the major causal factor for ischemic heart disease, stroke, lung cancer, COPD and numerous other tobacco-related diseases that affect almost every organ in the human body (4, 10)

Lukes Hospital, Patanamthitta, India Nikhil Kenny Thomas Faculty of Public Health, Universitas Sam Ratulangi (Sam Ratulangi University), Manado, Indonesia Jansje Henny Vera Ticoalu Timiryazev Institute of Plant Physiology, Russian Academy of Sciences, Moscow, Russia Mariya Vladimirovna Titova Laboratory of Public Health Indicators Analysis and Health Digitalization, Moscow Institute of Physics and Technology, Moscow, Russia Mariya Vladimirovna Titova Department of Health, Childrens Hospital 1, Ho Chi Minh City, Viet Nam Nghia Minh Tran School of Biomedical Engineering, University of Technology Sydney, Sydney, New South Wales, Australia Ngoc Ha Tran Department of Internal Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam Thang Huu Tran Department of Business Analytics, University of Massachusetts Dartmouth, Dartmouth, MA, USA Thang Huu Tran Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy Domenico Trico Faculty of Medicine, Tan Tao University, Long An, Viet Nam Thien Tan Tri Tai Truyen Department of Occupational Health and Safety, University of Development, Surabaya, Indonesia Abdul Rohim Tualeka Department of Internal Medicine, Wake Forest University, Winston-Salem, NC, USA Munkhtuya Tumurkhuu Department of Biosciences and Biotechnology, University of Medical Sciences, Ondo, Nigeria Aniefiok John Udoakang International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan Saeed Ullah College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia Shahid Ullah Lahore Business School, The University of Lahore, Lahore, Pakistan Muhammad Umar Department of Dietetics and Nutrition, Jimma University, Jimma, Ethiopia Tolassa Wakayo Ushula Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Seyed Mohammad Vahabi Department of Informatics and Radiology, Mayo Clinic, Rochester, MN, USA Sanaz Vahdati College of Health and Sport Sciences, University of Bahrain, Zallaq, Bahrain Asokan Govindaraj Vaithinathan Urmia University of Medical Sciences, Urmia, Iran Rohollah Valizadeh College of Public Health and Tropical Medicine, Jazan University, Jazan, Saudi Arabia Joe Varghese UKK Institute, Tampere, Finland Tommi Juhani Vasankari Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland Tommi Juhani Vasankari Department of Zoology, Central University of Punjab, Bathinda, India Balachandar Vellingiri Department of Human Genetics & Molecular Biology, Bharathiar University, Coimbatore, India Balachandar Vellingiri Department of Surgery, University of Southampton, Southampton, UK Georgios-Ioannis Verras College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK Georgios-Ioannis Verras Department of Health Policy and Management, Johns Hopkins University, Baltimore, MD, USA Dominique Vervoort Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA Manish Vinayak Department of Medical Oncology, University of Medicine and Pharmacy Grigore T Popa Iasi, Iai, Romania Simona Ruxandra Volovat Department of Medical Oncology, Regional Institute of Oncology, Iai, Romania Simona Ruxandra Volovat NUST School of Health Sciences, National University of Sciences and Technology (NUST), Islamabad, Pakistan Yasir Waheed Operational Research Center in Healthcare, Near East University, Nicosia, Turkey Yasir Waheed School of Life Course and Population Sciences, Kings College London, London, UK Yanzhong Wang Department of Parasitology, Rajarata University of Sri Lanka, Anuradhapura, Sri Lanka Kosala Gayan Weerakoon Institute of Clinical Epidemiology, Public Health, Health Economics, Medical Statistics and Informatics, Medical University Innsbruck, Innsbruck, Austria Peter Willeit Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK Peter Willeit Department of Public Health, Samara University, Samara, Ethiopia Abay Tadesse Woday Department of Emergency Medicine and Critical Care Nursing, Bahir Dar University, Bahir Dar, Ethiopia Yihun Miskir Wubie Cardiovascular Program, The George Institute for Global Health, Sydney, New South Wales, Australia Xiaoyue Xu Department of Environmental Health and Epidemiology, National Institute for Research in Environmental Health, Bhopal, India Vikas Yadav Department of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Amir Yarahmadi Department of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Amir Yarahmadi The George Institute for Global Health, Imperial College London, London, UK Sanni Yaya Department of Family Medicine, St

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