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Rare but serious: allergic reactions

However, some individuals report experiences that suggest possible associations between B12 and anxiety-like symptoms in certain contexts: High-dose supplementation : Some individuals report feeling 'overstimulated' or experiencing changes in energy levels when initiating B12 supplements

Side Effects Possible side effects include mild irritation at the injection site, allergic reactions, or, rarely, anaphylaxis

NAD+ precursor supplementation using NMN, NR, or NAD+ directly increases the input to the NAD+ salvage pathway