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Additionally, in lung cancer cells and osteosarcoma cells, LDHA phosphorylation at serine 196 by ULK1 promotes lactate generation, which subsequently induces PIK3C3 and Vps34 lactylation at lysine 356 and lysine 781, respectively

References: [1] Heffernan MA, et al

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Temperature excursions above 8C cause protein denaturation