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Both doses are increased gradually over several weeks to improve tolerability

doi: 10.1093/ajcn/39.5.722.[PubMed] Sies H (1999)

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A Randomized, Open-Label, Multicenter, Phase 3 Study of High-Dose Vitamin C Plus FOLFOX Bevacizumab versus FOLFOX Bevacizumab in Unresectable Untreated Metastatic Colorectal Cancer (VITALITY Study) Clin