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The IGF1R/INSR inhibitor BI 885578 selectively inhibits growth of IGF2-overexpressing colorectal cancer tumors and potentiates the efficacy of anti-VEGF therapy

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Flozins selectively inhibit SGLT2 and reduce glucose absorption, leading to glucosuria that is independent of insulin secretion

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Espley RV, Butts CA, Laing WA et al (2014) Dietary flavonoids from modified apple reduce inflammation markers and modulate gut microbiota in mice