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5B) was most likely due to its flux into NADP(H) production, where NADPH is required by xenobiotic detoxification enzymes for the metabolism of Dox

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Mol Endocrinol (2011) 25(9):152738

Although there are promising anecdotal reports and small-scale studies indicating benefits such as increased mental clarity, improved energy, and faster recovery during detox, its important to note that scientific evidence is still limited

Kubota et al., 2016) where addition of hemin to human hepatocytes and cell lines decreases ALAS1 protein expression via Lon and CLPXP, mediated by their interaction on the ALAS1 CP3 motif

EMBO J 30: 2044-2056