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A previous study has shown that despite reducing lipid oxidation, LA supplementation decreases hepatic fat content and the activity and mRNA expression levels of lipogenic enzymes (acetyl-CoA carboxylase [ACC], FAS, ATP-citrate lyase [ACLY], and PK) in the livers of rats fed a diet with 10% fat content, in which fish oil was replaced by vegetable oil to different proportions (20% and 100%), and another study (sesamin and LA) found the same

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There is also the potential for harmful drug-herb interactions and toxicity, along with a typically slower onset of action

Gut liver (2016) 10(5):70613

Melse-Boonstra, A