Based on the here-presented biochemical, structural and computational evidence, we propose that arGSTs utilize a GSH-dependent Brnsted base mechanism for conversion of the semi-stable LDOX product flavan-3,3,4-triol ( 4 ) or flavan-3-on-4-ol ( 7 ) into flav-2-en-3,4-diol ( 8 -B4), the 4-hydration species of cyanidin ( 8 ) (Extended Data Fig
Shaha, C., Tripathi, R
The ideal peptide approach addresses both the vascular compromise and the nerve damage itself
This product has not been approved by the FDA for human therapeutic use, dietary supplementation, or medical applications
In some cases, independent testing has revealed contaminants, degraded compounds, or dosages that are significantly higher or lower than advertised
10.2147/DDDT.S82030 7 KeremiB.LohinaiZ.KomoraP.DuhajS.BorsiK.JobbaGy-OvariG.et al (2009)