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215 Taking together, naringin promoted apoptosis by inducing mitochondrial membrane depolarization, endoplasmic reticulum stress, ROS production, and regulating MAPK and PI3K/Akt pathways

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It must be noted that the osmotic pressure adjustment in the control group should be made by adding mannitol or another suitable organic solute to the medium, because these are biocompatible and non-toxic, making it a suitable choice for adjusting osmotic pressure without interfering with the biological processes under study [183]