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Combination Therapy (Alpha-Blocker + 5-ARI) (Example: Jalyn ) Benefit: Immediate symptom relief + long-term reduction in prostate size Best for: Men with moderate-to-severe symptoms and large prostates Data from MTOPS Trial: Combination therapy delayed progression more than either drug alone Risk of progression reduced by 66% with combination therapy Also led to greater improvement in symptom scores and lower need for surgery 4

Studies demonstrate rapid systemic uptake and targeted activity at endothelial and fibroblastic levels, implicating it in nitric oxide modulation, collagen synthesis, and vascular repair

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Recent research into melanin and inhibitors of melanin synthesis has grown exponentially