The animal science is real, but calling it 'proven' is a stretch when 99.7% of the research is in rats
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PubMed Goldstein, A.L., Hannappel, E., Sosne, G., & Kleinman, H.K
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Gene expression analysis showed upregulation of survival pathways (Egr1, Akt1, Kras, Src, Foxo, Srf, VEGFR2, NOS1, NOS3) and downregulation of inflammatory mediators (NOS2, NFB)
This model mimics the tissue damage that occurs during a heart attack, and smaller infarcts generally translate to better outcomes and preserved heart function afterward