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Take B12 supplements separately from a B12-containing meal if possible

Additionally, a randomized, double-blind, placebo-controlled trial in 2,588 healthy older adults with mild hyperhomocysteinemia found that daily supplementation with 500 g of vitamin B 12 and 400 g of folic acid for two years reduced blood homocysteine concentrations but had no benefit on depressive symptoms in those with or without depressive symptoms at baseline (110)

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Pair with a balanced, calorieappropriate diet

Are there any side effects of B12 injections

Preventive Measures Taking preventive measures can also help mitigate some side effects