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Binding of Prx1 to long non-coding RNA LncFASA leads to phase separation, formation of Prx1-containing condensates, and subsequently ferroptotic cell death in triple-negative breast cancer [146]

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Based on commercially available analogues a preliminary structureactivity relationship study revealed that substitution of the amino position (R1, R2) showed broad tolerability of aliphatic groups and that lipophilic substituents of the phenyl group at the 3 position (R3) in the ortho and meta positions were well tolerated

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