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Each has its own evidence base and safety boundary

Despite wide dose ranges tested (6 g/kg to 20 mg/kg), multiple administration routes (intramuscular, intraperitoneal, intravenous, oral), and varied dosing frequencies across numerous animal models, no acute lethal dose has been identified

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Clinical success often depends on behavioral factors, baseline nutrient levels, and realistic goal setting

The number of clusters was determined using the sum of squared estimate of errors curve