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Local application at the swollen brain means a direct effect

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10.1186/2050-6511-13-8 BMC Pharmacol

Turhan H, Yasar AS, Basar N, Bicer A, Erbay AR, Yetkin E

For example, EECS was found to significantly increase the activity of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT), inhibit the activity and content of glutathione peroxidase (GPX) and malondialdehyde (MDA), and promote the levels of neurotransmitters such as NE and 5-HT [27]

Nausea, vomiting, and diarrhea beyond normal adaptation responses can occur with excessive doses