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Hypoxia, oxidative stress, and the interplay of hifs and nrf2 signaling in cancer

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Circ J 72(1):116

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2 The main sources of cellular ROS are mitochondria and nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, and peroxisomes containing xanthine oxidase and the inducible form of nitric oxide synthase, which produce superoxide anion and nitric oxide, respectively

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